Recovery from experimental autoimmune uveitis promotes induction of antiuveitic inducible Tregs
نویسندگان
چکیده
منابع مشابه
Pregnancy ameliorates induction and expression of experimental autoimmune uveitis.
Female patients suffering from autoimmune uveitis are reported to experience a temporary remission during pregnancy. Experimental autoimmune uveitis (EAU) is a model for human uveitis. Here we examine the effect of pregnancy on the development of EAU and its associated immunological responses. Susceptible C57BL/6 mice were immunized with interphotoreceptor retinoid-binding protein (IRBP). EAU s...
متن کاملExperimental autoimmune anterior uveitis. Induction with melanin-associated antigen from the iris and ciliary body.
PURPOSE This study was designed to investigate an animal model of uveitis that resembles anterior uveitis in humans after immunization with iris-ciliary body antigen. METHODS Male Lewis rats 6 to 8 weeks of age were immunized with the buffer- and detergent-insoluble bovine iris-ciliary body antigen mixed with complete Freund's adjuvant and pertussis toxin. Antigen was digested with various pr...
متن کاملMouse models of experimental autoimmune uveitis.
The mouse model of experimental autoimmune uveitis, induced by immunization of mice with the retinal protein IRBP, was developed in our laboratory 20 years ago and published in 1988. Since that time it has been adopted by many investigators and has given rise to many studies that helped elucidate genetic influences, dissect the basic mechanisms of pathogenesis and test novel immunotherapeutic p...
متن کاملRodent models of experimental autoimmune uveitis.
The model of experimental autoimmune uveitis (EAU) in mice and in rats is described. EAU targets immunologically privileged retinal antigens and serves as a model of autoimmune uveitis in humans as well as a model for autoimmunity in a more general sense. EAU is a well-characterized, robust, and reproducible model that is easily followed and quantitated. It is inducible with synthetic peptides ...
متن کاملExperimental autoimmune uveitis: cellular immune responsiveness.
N. Y. Supported by Grant Award EY 00699 from the National Institutes of Health, Bethesda, Md. Presented in part before the Spring Meeting of The Association for Research in Vision and Ophthalmology, April 1979. Submitted for publication Nov. 19. 1979. Reprint requests: E. I. Anderson, Ph.D., Department of Ophthalmology, Columbia University College of Physicians & Surgeons, New York, N. Y. 10032.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2015
ISSN: 0741-5400
DOI: 10.1189/jlb.3a1014-466rr